Magnetic remote actuation of soft materials is attractive for applications such as transforming materials and medical robots. However, due to manufacturing limitations, microscale magnetoactive devices are scarce and light-based additive manufacturing methods, despite achieving microscale resolution, struggle with particle-induced light scattering. Moreover, large hard-magnetic microparticles restrict ultimate feature sizes and deformation of soft-magnetic nanoparticle composites […]
Surface modifications of polycaprolactone (PCL) implants influence osseointegration by altering cell adhesion, proliferation, and differentiation. Osteon-like microtopography has been shown to enhance these parameters compared to untreated PCL. Additional treatments, such as cold atmospheric plasma (CAP) and extracellular matrix (ECM) coatings, may further improve bioactivity. This study evaluates and compares the osteogenic potential of osteon-like […]
Purpose Surface micropatterning is being explored as a strategy to mitigate thrombus formation and reduce long-term anticoagulation requirements in left ventricular assist devices (LVADs). This study investigated whether specific micro-topographies can modulate platelet deposition under LVAD supraphysiological wall shear stress (WSS) conditions. Materials and Methods A custom microfluidic platform was developed to generate a linear […]
The success of cardiovascular devices is hindered by non-physiological flow conditions and surface materials, which can trigger platelet activation and lead to thrombus formation with severe consequences for patients. While anticoagulation treatments help prevent thrombus formation, they can compromise hemostasis and thereby increase the risk of bleeding. In this study, physical surface modifications through specific […]
Two-photon polymerization (2PP) has garnered increasing attention for engineering hydrogels with tailored architectures and controlled cellular responses. However, current 2PP strategies typically rely on (meth)acrylated proteins and inefficient chain-growth crosslinking mechanisms. Although thiol-ene photo-click reactions can enhance 2PP efficiency, commercial water-soluble thiol crosslinkers (e.g., DTT—dithiothreitol) tend to form intramolecular loops and introduce structural defects due […]
