Application: Nanoimprint lithography (NIL)

The Influence of Micropatterned Surfaces on Platelet Adhesion to Reduce the Risk of Thrombus Formation in Left Ventricular Assist Devices

Purpose Surface micropatterning is being explored as a strategy to mitigate thrombus formation and reduce long-term anticoagulation requirements in left ventricular assist devices (LVADs). This study investigated whether specific micro-topographies can modulate platelet deposition under LVAD supraphysiological wall shear stress (WSS) conditions. Materials and Methods A custom microfluidic platform was developed to generate a linear […]

Micropatterned surfaces as biointerface to reduce platelet adhesion in cardiovascular devices

The success of cardiovascular devices is hindered by non-physiological flow conditions and surface materials, which can trigger platelet activation and lead to thrombus formation with severe consequences for patients. While anticoagulation treatments help prevent thrombus formation, they can compromise hemostasis and thereby increase the risk of bleeding. In this study, physical surface modifications through specific […]